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Fig. 7 | BMC Genomics

Fig. 7

From: Comprehensive epigenomic profiling of human alveolar epithelial differentiation identifies key epigenetic states and transcription factor co-regulatory networks for maintenance of distal lung identity

Fig. 7

MEF2C:FOXA1:NKX2–1 transcription factor heterotrimeric complexes are enriched in AT1-like cell type specific enhancers. A) Presence of predicted NKX2–1, MEF2C, and FOXA1 binding sites within the 92 AT1-like cell-specific enhancer regions. B) Example of one specific locus with an AT1-like cell type specific enhancer and the relative positioning of predicted FOXA1, NKX2–1, and TFBS. C) A549 cell line ChIP-seq of FOXA1 (blue) and NKX2–1 (green) distribution in AT1-like cell-specific enhancers. Tag Densities are centered on the middle of the cell type specific enhancer peak. D) IGV display of FOXA1 (blue), NKX2–1 (green), and MEF2C (red) expression levels during AEC differentiation. D0 = Day 0 (AT2), D2 = Day 2 (AT1.5, intermediate), D4 = D4 (AT1.5, intermediate), D6 = Day 6 (AT1-like)

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BMC Genomics

ISSN: 1471-2164

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