Table 2 Pathway and Network Genes and Proteins with GWAS SNPs
Gene Symbol | Pathway or Network | Trait |
|---|---|---|
APOA1 | HDAC1 Network PPARA Network XBP1 Network | Very low-density lipoprotein cholesterol |
ATG7 | KLF15 Network Sirtuin Signaling Pathway | Fat body mass |
CLIP1 | Remodeling of Epithelial Adherens Junctions | Body mass index |
FABP1 | HDAC1 Network PPARA Network | Non-alcoholic fatty liver disease Hepatic fibrosis |
GOT2 | Sirtuin Signaling Pathway | Triglycerides Aspartate aminotransferase |
MET | MITF Network Remodeling of Epithelial Adherens Junctions | Triglycerides |
MITF | MITF Network | Low-density lipoprotein cholesterol Triglycerides |
PNPLA2 | PPARA Network | Body fat distribution |
PPARA | PPARA Network | Type II Diabetes Total cholesterol Low-density lipoprotein cholesterol Triglycerides |
RAC1 | Actin Nucleation by ARP-WASP Complex Integrin Signaling Leukocyte Extravasation Signaling Paxillin Signaling | Low-density lipoprotein cholesterol |
RAP1GAP | Leukocyte Extravasation Signaling | Alkaline phosphatase |
SORT1 | MITF Network | Type II Diabetes Coronary artery disease LDL cholesterol change |
TNFRSF11B | Necroptosis Signaling Pathway | Alkaline phosphatase |