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Table 3 Norepinephrine enhanced expression of genes linked to acid resistance pathway 2 and evgS/evgA encoding a two-component signal transduction system

From: Genomewide transcriptional response of Escherichia coli O157:H7 to norepinephrine

Pathway/Gene groupa

Locus tag

Geneb

Gene function

Fold

changec

p adjusted

Acid resistance/Acid resistance pathway 2 (ARP2)

     
 

BHW77_01285

gadA

glutamate decarboxylase

+ 4.21

1.61E-03

 

BHW77_01290

gadX

transcriptional regulator

+ 3.27

3.18E-07

 

BHW77_01295

gadW

AraC family transcriptional regulator

+ 2.37

7.84E-04

 

BHW77_01315

gadE

transcriptional regulator

+ 3.72

5.69E-07

 

BHW77_01320

hdeD

protein

+ 4.76

9.22E-05

 

BHW77_01325

hdeA

acid stress chaperone

+ 3.46

9.30E-05

 

BHW77_01330

hdeB

acid stress chaperone

+ 3.94

8.70E-07

 

BHW77_14105

gadB

glutamate decarboxylase

+ 4.36

1.09E-03

 

BHW77_14110

gadC

glutamate:gamma-aminobutyrate antiporter

+ 5.02

6.32E-04

 

BHW77_07400

evgS

two-component system sensor histidine kinase

+ 2.10

5.37E-05

 

BHW77_07405

evgA

DNA-binding response regulator

+ 2.93

9.85E-21

  1. aGene group/gene designations were selected from RAST Server [109]
  2. bGene name and known or predicted functions are based on the annotated sequence of E. coli O157:H7 EDL 933 [110]
  3. c + Symbol represents that the gene expression listed in the column was upregulated