Fig. 2
From: Genetic architecture of protein expression and its regulation in the mouse brain
Proteome-wide profiling of mouse brain tissue. A 10-plex TMT-based global proteome analysis workflow. A total of 10 samples were analyzed by LC/LC-MS/MS. All proteomic data were analyzed using JUMP software. More than 228,000 distinct peptides, corresponding to 9979 proteins, were identified and quantified. B Principal-component analysis of all quantified proteins. C Histogram showing the coverage of proteomic data compared to RNAseq data from B6 and D2 mice. The open bar represents the distribution of protein coding genes detected by RNAseq, whereas the red bar indicates the distribution of protein coding genes from proteomic data. D Scatter plot showing a comparison of absolute expression between proteins and protein-coding transcripts. E Distribution of coefficient of variation (CV) for all proteins