Table 3 Commonly altered genes in HCE cells (cell line and primary) by CI1698 and CI1123
S. No | Genes | Description | Function |
|---|---|---|---|
1 | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3 | Inhibits NF-kB activity |
2 | ETS1 | Protein C-ets-1 | Transcription factor; Control expression of cytokines & chemokines |
3 | SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1 | Glucose transporter; Facilitate glucose transport to brain |
4 | RUNX1 | Runt-related transcription factor 1 | Attenuator of NF-kB signaling |
5 | ICAM1 | Intracellular adhesion molecule 1 | Transmembrane signaling receptor activity |
6 | LGALS3 | Galectin 3 | Ligand for galactose. Innate immune response |
7 | IKZF3 | Zinc finger protein aiolos | Regulation of lymphocyte differentiation |
8 | LILRB2 | Leukocyte immunoglobulin-like receptor subfamily B member 2 | Down regulation of immune responses and development of tolerance |