Fig. 3

Key signaling pathways and regulatory molecules drive boa intestinal regeneration. a Heatmap of canonical pathway activation and b URM activity from IPA, generated by each time point relative to fasted. c Overlapping pathway activity from genes significantly differentially expressed between fasted and 12hrpf. Circle size indicates “indegree”, or centralization within the network. d Phosphorylation patterns for three clusters of quantified phosphoproteins. e, f Kinase networks, indicating enrichment of specific kinases for clusters 1 and 2, with magnification of major groups of active kinases. g, h Top enriched Reactome pathways from phosphoprotein clusters