Fig. 7

Major intrinsic and extrinsic apoptosis pathway proteins in Crassostrea virginica and C. gigas. NCBI genome annotations for C. virginica (Ostreida) and C. gigas (Ostreida) revealed that the major intrinsic and extrinsic apoptosis pathway proteins are annotated in oysters. Proteins present in the C. gigas annotated genome and not in the C. virginica annotated genome are colored in gray and outlined with a black border. Proteins only in C. virginica are in grey. Potential multi-protein complexes are boxed with a dashed black line. Molecules from the novel cell death pathways necroptosis, parthanatos, and lysosome dependent cell death were also identified. Multiple (about 25%) model organism (D. melanogaster, C. elegans, H. sapiens) apoptosis and RCD proteins identified in the literature were not found in oyster annotated reference genomes, either due to errors in annotation or true absence in oysters