Fig. 3

Histone models identify five core histones-related features with strong effects on chromosome accessibility. A and B. Boxplots indicating the relative importance of each histone-related features in chromatin accessibility prediction in GM12878 (A) and HepG2 (B) cell lines. C and D. Barplots showing the AUC change of taking out each HM for chromatin accessibility prediction in GM12878 (C) and HepG2 (D) cell lines. E. AUCs in (C) and (D) were calculated by taking the average AUC of 10-folds cross validation. Barplots showing the AUC of HepG2 model in GM12878 HM signals and GM12878 model in GM12878 HM signals for GM12878 chromatin accessibility prediction. F. Barplots showing the AUC of GM12878 model in HepG2 HM signals and HepG2 model in HepG2 HM signals for HepG2 chromatin accessibility prediction. AUCs of GM12878 model in GM12878 HM signals and HepG2 model in HepG2 HM signals were calculated by taking the average AUC of 10-folds cross validation. AUCs of GM12878 model in HepG2 HM signals and HepG2 model in GM12878 HM signals were calculated by applying the model to a different test dataset