A systematic review and meta-analysis of host genetic factors associated with influenza severity

BMC Genomics

Table 1 Noteworthy results of meta-analyses assessing the association between host genetic factors and influenza disease severity. The entire set of results with meta-analyses performed using four different genetic models and stratified per ethnicity, study population or severity definition are available in Additional file 2

Gene	rs code	Genetic model	Heterozygote	Risk allele	Studies (n)	Cases (alleles) (n)	Controls (alleles) (n)	OR^a [95% CI]	I²	Venice score
IFITM3	rs12252	Allelic	CT	C	10	1422	2104	1.52 [1.06; 2.17]	54%	BCC
IFITM3	rs12252	Homozygous	CT	C	10	1422	2104	2.68 [1.22; 5.88]	29%	BBC
CCR5	rs333	Dominant	wt/Δ32	Δ32	4	934	990	1.20 [0.10; 13.83]	68%	BCC
FCGR2A	rs1801274	Allelic	AG	G	3	680	558	1.03 [0.70; 1.53]	0%	BAC
IFITM3	rs34481144	Allelic	AG	A	4	540	872	1.47 [0.24; 9.00]	83%	BCC

OR Odds ratio, IFITM3 Interferon-induced transmembrane protein 3, CCR5 C-C motif chemokine receptor 5, FCGR2A Fc fragment of IgG receptor IIa
^aPooled random effect odds ratio calculated using Peto’s method

ISSN: 1471-2164