Fig. 1

The reconstruction process of the lncRNA–miRNA–mRNA network. First, miRNA expression data were downloaded from two previous studies (GSE159507 and GSE159508). Second, differentially expressed mRNAs, lncRNAs, and miRNAs were screened. Third, target mRNAs of miRNAs were predicted using miRanda, and target lncRNAs of differentially expressed microRNAs were predicted using miRanda. Then, differentially expressed lncRNAs and mRNAs were merged with the target lncRNAs and mRNAs of differentially expressed miRNAs, respectively. The node degree of the selected lncRNA was more than 8. The coexpressed lncRNAs and mRNAs were selected (Pearson correlation coefficient > 0.90 and P < 0.001). Finally, the differentially expressed miRNAs, coexpressed lncRNAs and mRNAs were mapped into the interactions. lncRNA, long noncoding RNA; miRNA, microRNA; mRNA, messenger RNA