Table 3 Analysis of IL1A (rs1800587), IL1B (rs1143634), IL1RN (rs2234677) polymorphisms in relation to BMI. Due to the lack of AA genotype, only codominant model was analyzed (rs1800587). OR—odds ratio; CI—confidence interval; AIC—the Akaike information criterion
From: The interactions between interleukin-1 family genes: IL1A, IL1B, IL1RN, and obesity parameters
OVERBMI (n = 25) | % | CONBMI (n = 76) | % | OR | 95 %CI | p-value | AIC | |||
|---|---|---|---|---|---|---|---|---|---|---|
IL1A rs1800587 | ||||||||||
Codominant | C/C | 16 | 64.0 | 40 | 52.6 | 1.00 | 0.32 | 116 | ||
T/C | 9 | 36.0 | 36 | 47.4 | 0.62 | 0.25 | 1.59 | |||
IL1B rs1143634 | ||||||||||
Codominant | C/C | 11 | 44.0 | 40 | 52.6 | 1.00 | 0.50 | 117.6 | ||
T/C | 11 | 44.0 | 32 | 42.1 | 1.25 | 0.48 | 3.25 | |||
T/T | 3 | 12.0 | 4 | 5.3 | 2.73 | 0.53 | 14.04 | |||
Dominant | C/C | 11 | 44.0 | 40 | 52.6 | 1.00 | 0.45 | 116.5 | ||
T/C-T/T | 14 | 56.0 | 36 | 47.4 | 1.41 | 0.57 | 3.51 | |||
Recessive | C/C-T/C | 22 | 88.0 | 72 | 94.7 | 1.00 | 0.28 | 115.9 | ||
T/T | 3 | 12.0 | 4 | 5.3 | 2.45 | 0.51 | 11.81 | |||
Overdominant | C/C-T/T | 14 | 56.0 | 44 | 57.9 | 1.00 | 0.87 | 117.0 | ||
T/C | 11 | 44.0 | 32 | 42.1 | 1.08 | 0.43 | 2.69 | |||
IL1RN rs2234677 | ||||||||||
Codominant | G/G | 17 | 68.0 | 35 | 46.1 | 1.00 | 0.15 | 115.3 | ||
A/G | 7 | 28.0 | 37 | 48.7 | 0.39 | 0.14 | 1.05 | |||
A/A | 1 | 4.0 | 4 | 5.03 | 0.51 | 0.05 | 4.97 | |||
Dominant | G/G | 17 | 68.0 | 35 | 46.1 | 1.00 | 0.05 | 113.3 | ||
A/G-A/A | 8 | 32.0 | 41 | 53.9 | 0.40 | 0.15 | 1.04 | |||
Recessive | G/G-A/G | 24 | 96.0 | 72 | 94.7 | 1.00 | 0.80 | 117.0 | ||
A/A | 1 | 4.0 | 4 | 5.03 | 0.75 | 0.08 | 7.04 | |||
Overdominant | G/G-A/A | 18 | 72.0 | 39 | 51.3 | 1.00 | 0.07 | 113.7 | ||
A/G | 7 | 28.0 | 37 | 48.7 | 0.41 | 0.15 | 1.09 | |||