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Fig. 1 | BMC Genomics

Fig. 1

From: Identification of cardiomyopathy-related core genes through human metabolic networks and expression data

Fig. 1

Flow chart of this study. Step 1: mining the initial modules from the network modules mined by MCODE according to DEGs. Step 2: detection of candidate modules based on the significance of the Pearson correlation coefficient difference score of the initial modules. Step 3: identification of the cardiomyopathy risk modules significantly related to DCM and ICM according to the importance of the module score based on Markov random field. Step 4: identification of core genes from the cardiomyopathy risk module based on the shortest path between known disease-causing genes. Step 5: evaluation of core genes from three aspects: enrichment analysis, literature confirmation and classification efficiency

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BMC Genomics

ISSN: 1471-2164

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