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Fig. 2 | BMC Genomics

Fig. 2

From: Cyclical regression covariates remove the major confounding effect of cyclical developmental gene expression with strain-specific drug response in the malaria parasite Plasmodium falciparum

Fig. 2

Comparison of P. falciparum transcriptional profiles of two features in strains HB3 and 3D7 data. A: Correct assignment of 0 hpi shows little difference in the expression of PF3D7_1034400 between HB3 and 3D7. B: An 8 h shift in HB3 IDC progression timing produces differential expression at 20 h and 40 h due to the progression shift. C: In PF3D7_0926700, a genuine expression difference exists between HB3 and 3D7 at 40 hpi. D: An 8 h shift in HB3 expression obscures the differential expression at 40 h, and generates a difference at 20 h; the misalignment creates both Type I and Type II errors. Figures A, B, C, and D are derived from transcriptional time course data from HB3 and 3D7 [15, 33].

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BMC Genomics

ISSN: 1471-2164

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