Fig. 4

PRDM9 motif binding predictions (A) Array binding predictions with ZnFs#3-#6 “core motif” boxed (B) Pie chart of the population frequency of “core motifs” across all individuals (C) Identical “core motif” combinations are predicted to result in fully symmetric binding and efficient DSB formation [3, 4] (D) variants with somewhat dissimilar motifs, are predicted to result in some degree of asymmetry. In humans, a similar degree of motif-match still allowed DSBs necessary for successful recombination [3, 4, 29] (E) hypothetical combination of the most common variant of minke whale species of two hemispheres, generating a putative interspecies hybrid combination. Asymmetric positioning of recombination initiation sites would be predicted, which is implicated in F₁-hybrid male sterility in mammals [30]