Fig. 4

Large cancer datasets show extended and regional mutation patterns. a Heatmap depicting the relative contribution of the indicated mutation types and the surrounding bases to the point mutation spectrum for metastatic melanomas. The total number of somatic point mutations is indicated. Only C > T substitutions are shown, because other substitution types are much less common. b Relative contribution of each C > T trinucleotide change to the point mutation spectrum split between different genomic regions. c Graph depicting the similarity in the mutation profile between genomic windows and the rest of the genome. Each dot shows the cosine similarity between the mutation profiles of a single window and the rest of the genome. The dots are colored based on the sizes in mega bases of the windows. The IGK (chr2), IGH (chr14) and IGL (chr22) loci are visualized with vertical orange lines [31]. The width of the lines is set at 1 pt., because using the actual widths of these loci results in lines that are too small to be visible