Fig. 3

TC-hunter performance evaluation and detection level. A Time and resources consumption of TC-hunter using simulated data (human Orc6 in D. melanogaster), every step in the pipeline is illustrated. B Confusion matrix showing the performance of TC-hunter for 35 samples (simulated and biological data). TP, true positive; FP, false positive; FN, false negative; TPR, true positive rate; PPV, positive prediction value and F₁-score, harmonic mean of precision vs sensitivity. C Correlation between average coverage of a sample and the score from the predicted TIS. TIS from simulated data are shown in blue. TIS from real biological data are shown in brown (best candidate) and orange (secondary predictions). True positive predictions are shown as filled circles, false positives are open circles and predictions that were not experimentally validated are shown as asterisks and thus, not joined with a line