Table 1 Gene expressions associated with melanogenesis
Gene | Symbol | WLS vs CB (Fold change) | WLS vs CH (Fold change) | ||
|---|---|---|---|---|---|
Full name | RNA-Seq | qPCR | RNA-Seq | qPCR | |
premelanosome protein | PMEL | 8.98 | 9.24 | 8.35 | 8.96 |
tyrosinase related protein 1 | TYRP1 | 8.27 | 10.54 | 7.41 | 6.54 |
tyrosinase | TYR | 7.05 | 8.23 | 7.15 | 5.43 |
melan-A | MLANA | 6.04 | 7.23 | 6.84 | 7.34 |
melanophilin | MLPH | 5.33 | 5.62 | 8.28 | 9.23 |
premelanosome protein 17 | Pmel17 | 5.95 | 4.89 | 5.58 | 4.98 |
G protein-coupled receptor 143 | GPR143 | 6.36 | 7.23 | 2.91 | 3.43 |
aldehyde dehydrogenase 1 family member A1 | ALDH1A1 | 3.28 | 4.12 | 1.69 | 1.89 |
endothelin 3 | EDN3 | 2.27 | 2.87 | 1.95 | 2.45 |
endothelin receptor B subtype 2 | EDNRB2 | 2.15 | 3.23 | 4.62 | 5.62 |
cyclin dependent kinase inhibitor 2B | CDKN2B | 1.74 | 3.23 | 3.39 | 4.56 |
PDZ domain containing 1 | PDZK1 | 2.14 | 4.12 | 2.54 | 3.23 |
PDZK1 interacting protein 1 | PDZK1IP1 | 1.45 | 2.43 | 2.54 | 2.98 |
dopachrome tautomerase | DCT | 7.99 | 8.35 | 2.13 | 3.12 |
cAMP responsive element binding protein 3 like 3 | CREB3L3 | NS | 3.21 | 4.74 | 3.43 |
wingless-type MMTV integration site family, member 11b | WNT11B | NS | 2.12 | 3.87 | 2.98 |
frizzled class receptor 5 | FZD5 | NS | 2.43 | 2.63 | 3.23 |
melanocortin 5 receptor | MC5R | NS | 2.16 | 2.26 | 2.98 |
alcohol dehydrogenase 1C (class I), gamma polypeptide | ADH1C | 1.59 | 1.98 | NS | 2.01 |
MET proto-oncogene, receptor tyrosine kinase | MET | NS | 3.32 | 1.57 | 1.79 |
phospholipase C beta 4 | PLCB4 | NS | 2.12 | 1.28 | 2.01 |
alcohol dehydrogenase 6 (class V) | ADH6 | 1.05 | 1.83 | NS | 2.12 |
G protein subunit alpha o1 | GNAO1 | NS | −2.65 | −3.21 | −2.32 |
interleukin 4 induced 1 | IL4I1 | −1.61 | − 2.32 | NS | − 1.98 |
4-hydroxyphenylpyruvate dioxygenase | HPD | −1.58 | −2.76 | NS | −2.32 |
Transcription factors | |||||
 forkhead box A1 | FOXA1 | 2.43 | 4.32 | 6.06 | 5.35 |
 transcription factor AP-2 beta | TFAP2B | 5.26 | 5.43 | 4.35 | 4.67 |
 transcription factor AP-2 alpha | TFAP2A | 3.46 | 5.12 | 5.55 | 6.45 |
 transcription factor 21 | TCF21 | 1.31 | 2.32 | 5.04 | 4.34 |
E74 like ETS transcription factor 3 | ELF3 | 1.52 | 2.32 | 4.74 | 3.76 |
SRY-box 10 | SOX10 | 1.95 | 2.32 | NS | 2.42 |
activating transcription factor 3 | ATF3 | 3.04 | 4.32 | NS | 4.87 |
runt-related transcription factor 1 | RUNX1 | −2.54 | −1.98 | NS | −2.43 |
JunD proto-oncogene, AP-1 transcription factor subunit | JUND | 1.77 | 2.22 | NS | 2.54 |
MAF bZIP transcription factor A | MAFA | 1.6 | 2.01 | NS | 1.98 |
SAM pointed domain containing ETS transcription factor | SPDEF | NS | 2.31 | 4.33 | 3.21 |