Skip to main content

Table 3 Cofitness clusters of genes. Common genes between the two studies are italicized.

From: The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures

GO:ID

GO term;

HIPLAB cofit cluster genes

HIPLAB cofit

NIBR cofit cluster genes

NIBR cofit

GO:0030491

DNA heteroduplex formation; camptothecin

CDC31, DML1, FPS1, LSM1, MMS4, MUS81, RAD55RAD57, RAD59, RHO1, RPN4, RSC58, SUP45, YTH1

0.62

CSM3, DDC1, MMS4, MUS81, PPH3, RAD17, RAD54 , RAD55, RAD57, RAD59, RPL26B, RTT101, SAE2, SRS2

0.67

GO:0006289

DNA Nucleotide excision repair; mechlorethamine

MMS2, RAD1, RAD10, RAD14, RAD2, RAD23, RAD4, RAD5

0.94

MMS2, MPH1, PSO2, RAD1, RAD10, RAD14,RAD18, RAD2, RAD23, RAD4, RAD5, REV1, REV3, WSS1

0.83

GO:0000463

Maturation of LSU-RRNA from tricistronic transcript; 5-fluorouracil

RRP15, RRP42

0.99

MAK5, MAS2, RRP15, TRM10

0.95

GO:0046654

Tetrahydrofolate biosynthesis; methotrexate

APM3, CDC21, DFR1, FOL2YBT1

0.76

DFR1, FOL1, FOL2YBT1

0.97

GO:0000294

Nuclear transcribed mRNA catabolic process; 6-azauridine

POP1, POP4, POP7, RPP1

0.85

AMD1, HAM1, POP1, POP4

0.97

GO:0008202

Steroid metabolism; fluconazole

ERG11, FPR1, HMG1, PKC1, RIM101, RIM13, RIM21, RIM9, SNF7, UTR1, YGR122W

0.57

DAP1, ERG11, GCS1, LAA1, MIL1, NCP1, TVP18, UPC2

0.91

GO:0031929

Tor signaling; rapamycin

AVL9, BRL1, CDC20, GLC7, GTR1, GTR2, IKI3, KOG1, KTI12, MEH1, MOD5, NCS2, NCS6, PEP7, RPL34B, RTG2, SER2, SHE4, SLM4, THR4, TIM54, TOR1TOR2, VAM6, VAM7, VPS27, VPS29, VPS35

0.87

APL5, APL6, APS3, ARF1, CKA2, ERG5, HUR1, KOG1, LSM4, MAK10, MCM2, PHO80, SEM1, TOR1, TOR2VAM6, YPP1

0.89

GO:0007021

Tubulin complex assembly; nocodazole

ARP6, CCT2, CCT4, CCT5, CIN2, PAC2, PAN2, PAN3SNQ2, SWC3, SWC5, SWR1, TCP1, TUB3, VPS71

0.85

ARP6, BIK1, CCT2, CCT4, CCT5, CIN2, CIN4, PAC2, PAN2, PAN3, RBL2, SNQ2, SWC3SWC5, SWR1, TCP1, TUB3, VPS71

0.94.

GO:0030968

Endoplasmic reticulum unfolded protein response; tunicamycin

ALG7, BCK1, CNB1, FYV8, GFA1, HAC1, IRC21, IRE1NHX1,RET2,SEC21,SEC26,SPF1

0.77

ACK1, ALG7, CNB1, COP1, FYV8, GFA1, HAC1, IPK1, IRC21, IRE1, NHX1, RET2, SEC21, SEC26, SPF1

0.87