Fig. 4

Transcript graph of a gene showing several alternative transcripts encoding a same CDS. The Ensembl identifiers of orthologous genes are ENSG00000173065,ENSMUSG00000037750 and ENSCAFG00000031142. These are identified as orthologous genes structurally conserved, sharing a common gene model: [A<>B>C[D]. (a) The transcript graph obtained comprises two sugraphs: one is a triplet (right of Fig. 4a), and the other is made up of more than three nodes (left of Fig. 4a). In fact, ENST00000452648 and ENST00000581407 transcripts in human (blue nodes) encode the same CDS with a structure model [ABCD]. Both transcripts have different UTR regions resulting from alternative transcription initiation and termination, as illustrated in Fig. 4b. This is also the case for the ENSMUST00000155571 and ENSMUST00000073705 transcripts in mouse (grey nodes). (b) Representation of the UTR exons from the alternative transcripts encoding the same CDS. Coding exons are shown as boxes and UTR exons as dashed boxes. Introns are shown as lines. The bottom of the figure shows the gene regions, including the 5’UTR, CDS and 3’UTR exons