Fig. 6
From: Identifying genes with conserved splicing structure and orthologous isoforms in human, mouse and dog
Site graph and transcript graph: identification of CDS orthology groups across three species. (a) The pairwise alignment of gene models indicates site and block orthology relationships and predicts new feasible elements (e.g., block ‘C’ and its flanking sites ‘ >C]’ in gene j, see Fig. 5). The orthology relations are linked in a multi-species site graph (bottom of Fig. 6a), where nodes are functional sites, edges are orthology relations, and ‘ ?’ indicates predicted sites. (b) Determination of CDS orthology groups. Transcript graphs were built using pairwise transcript orthology. The example illustrates two CDS orthology groups. A first group involves three known orthologous CDSs. A second group of two CDSs is made up of a known CDS in gene i and a predicted CDS in gene j (‘ ?’ symbol). Gene k cannot form the third orthologous CDS due to the lack of an element in the gene