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Table 1 The readthrough rules derived from natural suppressor tRNAs for nonsense mutations

From: Frameshift and wild-type proteins are often highly similar because the genetic code and genomes were optimized for frameshift tolerance

Site tRNA (AA) Codon
supD Ser (S) UAG
supE Gln (Q) UAG
supF Tyr (Y) UAG
supG Lys (K) UAA
supU Trp (W) UGA