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Table 1 Characteristics of the instrumental variables for glutamate and aspartate and the causal associations bewteen glutamate and aspartate with prostate and breast cancers

From: Effects of glutamate and aspartate on prostate cancer and breast cancer: a Mendelian randomization study

Exposure

SNPs

Genea

Chromosome

Effect allele

Association with exposure

Association with prostate cancer

Association with breast cancer

Betab

SEc

P value

r2

F

Betab

SEc

P value

Betab

SEc

P value

Glutamate

SNP with genome-wide significance

    

—

   

—

—

—

—

—

—

rs239614

LOC102724355

21

G

0.28

0.06

4.70E-08

0.0111

22

0.0080

0.0116

0.4895

0.0115

0.0087

0.1857

Additional SNPs with P < 5 × 10−6

              

rs261076

DOCK2

5

A

-0.16

0.05

1.90E-06

0.0051

10

0.0091

0.0100

0.3579

0.0105

0.0075

0.1584

rs495578

PDZD2

5

A

-0.17

0.04

3.30E-06

0.0091

18

0.0047

0.0105

0.6570

0.0056

0.0080

0.4845

rs41308216

PIKFYVE

2

G

-0.85

0.16

4.20E-06

0.0141

28

0.0114

0.0304

0.7077

-0.0294

0.0237

0.2149

rs10973935

ANKRD18A

9

G

-0.35

0.09

4.30E-06

0.0076

15

-0.0054

0.0184

0.7701

0.0024

0.0139

0.8623

Aspartate

SNP with genome-wide significance

              

rs33966350

ENPEP

4

A

-1.5

0.19

1.40E-17

0.0307

62

-0.0425

0.0375

0.2565

-0.0443

0.0272

0.1031

rs113141482

GPR158

10

A

-0.98

0.19

1.00E-09

0.0136

27

-0.1032

0.0497

0.0379

-0.0185

0.0377

0.6233

rs189080637

—

3

A

-0.98

0.21

4.30E-08

0.0111

22

-0.0370

0.0420

0.3779

-0.0488

0.0315

0.1214

Additional SNPs with P < 5 × 10−6

              

rs113367140

RTP4

3

A

-0.54

0.13

7.30E-08

0.0086

17

-0.0179

0.0229

0.4348

0.0113

0.0176

0.5195

rs6894601

—

5

G

-0.16

0.04

1.90E-06

0.0081

16

-0.0057

0.0088

0.5158

0.0083

0.0066

0.2078

rs114190931

JARID2

6

T

0.68

0.14

2.10E-06

0.0121

24

-0.0077

0.0241

0.7505

0.0380

0.0187

0.0425

rs76197627

MGRN1

16

T

-0.49

0.13

2.20E-06

0.0071

14

-0.0315

0.0289

0.2754

-0.0038

0.0224

0.8634

rs117109641

APBA2

15

T

0.65

0.17

2.40E-06

0.0076

15

0.0084

0.0321

0.7931

-0.0079

0.0240

0.7421

rs35355649

MORN1

1

T

-0.17

0.05

2.60E-06

0.0061

12

0.0051

0.0097

0.6001

0.0010

0.0072

0.8932

rs57037252

ZNF559

19

T

-0.36

0.08

3.10E-06

0.0101

20

0.0088

0.0151

0.5596

-0.0032

0.0113

0.7742

rs79447732

DLGAP2

8

G

-0.54

0.14

3.40E-06

0.0076

15

0.0223

0.0269

0.4065

-0.0101

0.0200

0.6113

rs137948393

SLC4A5

2

G

0.41

0.13

3.90E-06

0.0051

10

0.0673

0.0341

0.0487

0.0086

0.0260

0.7401

rs75527467

ITPR1

3

T

1

0.3

4.10E-06

0.0056

11

0.0822

0.0389

0.0348

-0.0142

0.0365

0.6974

  1. a DOCK2 Dedicator of Cytokinesis 2, PDZD2 PDZ Domain containing 2, PIKFYVE Phosphoinositide Kinase, FYVE-type zinc finger containing, ANKRD18A Ankyrin Repeat Domain 18A, ENPEP glutamyl arninopeptidase, GPR158 G Protein-coupled Receptor 158, RTP4 Receptor Transporter Protein 4, JARID2 Jumonji and AT-rich Interaction Ddomain containing 2, MGRN1 Mahogunin Ring finger 1, APBA2 Amyloid Beta precursor Protein Binding family A member 2, ZNF559 Zinc Finger Protein 559, DLGAP2 DLG Associated Protein 2, SLC4A5 Solute Carrier family 4 member 5, ITPR1 Inositol 1,4,5-trisphosphate receptor type 1
  2. b Beta, per allele effect on exposure or outcomes
  3. c SE Standard Error
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BMC Genomics

ISSN: 1471-2164

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