Effects of glutamate and aspartate on prostate cancer and breast cancer: a Mendelian randomization study

BMC Genomics

Table 2 MR analysis using different methods for genetic associations between aspartate and prostate cancer^a

MR method	Association					Heterogeneity
MR method	Estimate	SE^b	95% CI (Down)	95% CI (Up)	P-value	Q	P-value
Simple median	0.038	0.030	-0.021	0.096	0.206
Weighted median	0.032	0.023	-0.012	0.077	0.155
Penalized weighted median	0.032	0.023	-0.012	0.077	0.155
IVW	0.042	0.020	0.003	0.081	0.034	1.868	0.3932
Penalized IVW	0.042	0.020	0.003	0.081	0.034
Robust IVW	0.041	0.013	0.015	0.068	0.002
Penalized robust IVW	0.041	0.013	0.015	0.068	0.002
MR-Egger	-0.042	0.097	-0.232	0.147	0.660
MR-Egger intercept	0.106	0.118	-0.126	0.338	0.370
Penalized MR-Egger	-0.042	0.097	-0.232	0.147	0.660
Penalized MR-Egger intercept	0.106	0.118	-0.126	0.338	0.370
Robust MR-Egger	-0.042	0.046	-0.131	0.047	0.354
Robust MR-Egger intercept	0.106	0.068	-0.028	0.240	0.121
Penalized robust MR-Egger	-0.042	0.046	-0.131	0.047	0.354
Penalized robust MR-Egger intercept	0.106	0.068	-0.028	0.240	0.121
Robust adjusted profile score	0.043				0.041

^aSingle nucleotide polymorphisms with genome-wide significance (P < 5 × 10^–8) were used as genetic predictors
^bSE Standard Error

ISSN: 1471-2164