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Table 4 Replicated birthweight-associated sites in meta-analysis

From: DNA methylation changes in cord blood and the developmental origins of health and disease – a systematic review and replication study

Site

Chr

Position

Gene

Estimate (CI)

Nominal P value

Adjusted P value

Literature estimate (CI)

Author (PMID)

cg26995690

13

36,346,376

DCLK1

-13.8 (-22.4, -5.2)

0.0017

0.020

-48.7 (-62.9, -34.5)

Kupers et al. 31,015,461

cg00637745

2

121,497,334

-

-35.9 (-58.6, -13.3)

0.0019

0.023

-20.9 (-26.8, -15.1)

Kupers et al. 31,015,461

cg07133097

2

121,497,538

-

-21.9 (-35.8, -7.9)

0.0021

0.025

-29.2 (-37.5, -20.8)

Kupers et al. 31,015,461

  1. Chr: chromosome; CI: confidence interval; Adjusted P value: Bonferroni-corrected p value; Published estimate: coefficients from Kupers at al birthweight meta-analysis of all ancestries (PMID: 31,015,461). Analyses were adjusted for maternal age, sex, maternal smoking, gestational age, study centre and cellular composition. The estimates are expressed as the change in methylation beta values per one unit change in birthweight (grams)