Sex-specific genetic modifiers identified susceptibility of cold stored red blood cells to osmotic hemolysis

BMC Genomics

Table 1 Top SNPs in comparing the p-value differences between sex-stratified GWAS for osmotic hemolysis

rsID	Gene	Chr	A1	A2	AF (A1)	Males (n = 6,127)		Females (n = 6,102)		P-value difference test^b
rsID	Gene	Chr	A1	A2	AF (A1)	β-value (A1)	P-value	β-value (A1)	P-value	P-value
rs2518489^a	SPTA1	1	G	A	0.28	1.42	3.28E-08	1.93	2.85E-16	8.67E-09
rs9788072	KCNA6	12	A	G	0.11	0.13	0.74	-2.04	3.56E-08	4.81E-08
rs13306780^a	SLC4A1	17	A	C	0.41	0.51	0.043	1.37	3.14E-09	7.28E-08
rs6068661^a	SUMO1P1	20	A	G	0.44	-1.27	2.53E-07	0.014	0.95	2.66E-07
rs11123179	PAX8	2	C	T	0.20	-1.47	4.77E-07	0.0028	0.99	4.81E-07

^aThese are representatives of other similar SNPs in the same loci
^bThis column shows the p-value based on testing the p-value difference between male- and female-specific GWAS for osmotic hemolysis

ISSN: 1471-2164