Table 1 Functional annotation analysis of DEGs common to all experimental comparisons

Term

Count

P Value

Enriched

Genes

regulation of cellular process

13

0.0049

1.69

TMOD1, MPP1, PDIA6, SAT1, FOSL2, HSP90B1, DHFR, STIM2, ID1, TAX1BP1, S100A6, RGN, PCBD1

regulation of biological process

13

0.0085

1.60

TMOD1, MPP1, PDIA6, SAT1, FOSL2, HSP90B1, DHFR, STIM2, ID1, TAX1BP1, S100A6, RGN, PCBD1

tetrahydrobiopterin biosynthetic process

2

0.0086

214.14

DHFR, PCBD1

tetrahydrobiopterin metabolic process

2

0.0086

214.14

DHFR, PCBD1

pteridine-containing compound biosynthetic process

2

0.0158

116.81

DHFR, PCBD1

biological regulation

13

0.0179

1.50

TMOD1, MPP1, PDIA6, SAT1, FOSL2, HSP90B1, DHFR, STIM2, ID1, TAX1BP1, S100A6, RGN, PCBD1

cellular homeostasis

4

0.0190

6.28

STIM2, RGN, PDIA6, HSP90B1

pteridine-containing compound metabolic process

2

0.0257

71.38

DHFR, PCBD1

cellular metal ion homeostasis

3

0.0409

8.53

STIM2, RGN, HSP90B1

Term

Count

P Value

Enriched

Genes

extracellular exosome

6

0.0202

3.21

TAX1BP1, S100A6, TARS, PCBD1, PDIA6, HSP90B1

extracellular vesicle

6

0.0206

3.19

TAX1BP1, S100A6, TARS, PCBD1, PDIA6, HSP90B1

extracellular organelle

6

0.0207

3.19

TAX1BP1, S100A6, TARS, PCBD1, PDIA6, HSP90B1

extracellular region

7

0.0281

2.49

TAX1BP1, S100A6, RGN, TARS, PCBD1, PDIA6, HSP90B1

cytoplasm

11

0.0287

1.61

MPP1, TMOD1, STIM2, ID1, S100A6, RGN, TARS, PCBD1, PDIA6, SAT1, HSP90B1

membrane-bounded vesicle

6

0.0439

2.64

TAX1BP1, S100A6, TARS, PCBD1, PDIA6, HSP90B1

Term

Count

P Value

Enriched

Genes

tropomyosin binding

2

0.0136

135.43

TMOD1, S100A6