Table 1 The subset of top genes with experimental variants associated with CD (abstracts > 15)
Gene | Abstracts | Panels | GWAS catalog studies | ClinVar |
|---|---|---|---|---|
NOD2 | 751 | 16 | 8 | Yes |
TNF | 156 | 0 | 0 | Yes |
IL23R | 148 | 1 | 6 | Yes |
ATG16L1 | 128 | 1 | 5 | Yes |
TLR4 | 88 | 0 | 0 | No |
IL10 | 86 | 2 | 1 | Yes |
SLC22A4 | 73 | 0 | 0 | Yes |
IRGM | 60 | 1 | 3 | Yes |
SLC22A5 | 50 | 0 | 0 | Yes |
TNFSF15 | 45 | 0 | 4 | No |
NOD1 | 41 | 0 | 0 | No |
IL6 | 41 | 4 | 0 | Yes |
IL1B | 40 | 0 | 0 | No |
STAT3 | 37 | 1 | 2 | No |
NFKB1 | 36 | 0 | 0 | No |
DLG5 | 35 | 0 | 0 | No |
IL12B | 34 | 0 | 0 | No |
ABCB1 | 33 | 1 | 0 | Yes |
KRAS | 33 | 0 | 0 | No |
PTPN22 | 31 | 0 | 0 | No |
IL1RN | 29 | 0 | 0 | No |
IL23A | 28 | 0 | 0 | No |
CD14 | 28 | 0 | 0 | No |
PTPN2 | 24 | 0 | 0 | No |
IL10RA | 20 | 2 | 0 | Yes |
NLRP3 | 19 | 0 | 0 | No |
MEFV | 20 | 1 | 0 | No |
IL4 | 18 | 0 | 0 | No |
NKX2–3 | 17 | 0 | 0 | No |
ICAM1 | 16 | 0 | 1 | No |
IFNG | 16 | 0 | 0 | No |
TLR9 | 16 | 0 | 0 | No |