Fig. 4

Dynamics of liver chromatin accessibility and gene expression as a function of genomic location (A), Chromatin accessibility and gene expression are positively correlated. 3 MA biplots showing genome-wide gene expression and overlain differentially accessible regions at gene bodies at T2, T3 and T4 compared to T1. Accessibility levels are shown in red-blue spectrum reflecting open- to closed chromatin states at gene bodies and the corresponding gene expression in grey colour (B), Regression analyses conducted on significant DARs located at gene bodies and gene expression data. The table shows that accessibility at T2 explains the majority of the observed differential expression throughout the experiment. Red squares highlight the correlation of the paired accessibility and expression data of the same time point (C), The genomic distribution of co-accessible DARs clusters across gene models in the salmon genome, promoter defined as genomic regions located 5 kb upstream of TSSs (D), Multi-omic heatmaps showing mean accessibility and expression at each of the four time points per genomic location