Fig. 7

Analysis of mutations in samples sequenced on the GridION and the MiSeq: Consensus genomes produced by Genome Detective were uploaded to Nextclade and the results were analyzed. RUN116 was run on both platforms and the number and type of mutations detected by each platform was compared using a Wilcoxon rank sum test (Fig. A and C). A consensus file for all runs, for each platform, was produced and uploaded to Nextclade and a Wilcoxon rank sum test was performed to compare the number and type of mutations detected by both platforms (Fig. B and D). GridION samples are represented in yellow, whilst MiSeq samples are presented in green. Deletions, insertions, and substitutions are represented in pink, green, and blue, respectively. Statistical significance (Wilcoxon p tests) is represented by “*” (ns: non-significant, ***: p < 0.001, ****: p < 0.0001)