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Table 2 miRNA-mRNA Correlations Predicted by mirTarRnaSeq and Significantly Differentially Expressed in SARS-CoV-2 Infected vs Uninfected Controls Across 3 Time Points. Significant correlations between miRNA-mRNA for SARS-CoV-2 infected vs uninfected control cells differentially miRNA and mRNA expression (P < 0.05). Pink cell color signifies previously known miRNA-mRNA interactions (Tarbase v8), and green cell color represents known associated with endothelial damage due to SARS-CoV-2 infection [38]. Correlation value is the level of inverse correlation of miRNA and mRNA regulation estimated by mirTarRnaSeq observed in the dataset (− 1,0), where − 1 is at the most inverse correlation observed in the dataset). Target scan CSP represents context score percentile (between 1 and 100, where 100 is the highest score possible). mirTarRnaSeq p value calculation is described in the results section, the DE p value is estimated from differential expression analysis performed using DESeq2. NA represents a site not predicted as the target of miRNA by TargetScan

From: mirTarRnaSeq: An R/Bioconductor Statistical Package for miRNA-mRNA Target Identification and Interaction Analysis

miRNA Gene Symbol Correlation Value miRanda Score TargetScan CSP mirTarRnaSeq p value p value mRNA DE p value miRNA DE
hsa-miR-17-5p SSH1 −0.99 169 94 0.01807 0.001407784 0.00074288
hsa-miR-93-5p MAPK1 −0.99 169 96 0.0005 0.038078634 0.001500608
hsa-miR-93-5p HOMER2 −0.99 169 NA 0.00293 0.028214162 0.001500608
hsa-miR-23c ABL2 −0.99 173 74 0.00136 0.027869177 0.0258363
hsa-miR-374a-5p LARP1 −0.99 171 65 0.03374 0.01177344 4.25E-11
hsa-miR-429 LONRF2 −0.99 169 68 0.02127 0.018978845 1.01E-05