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Table 2 miRNA-mRNA Correlations Predicted by mirTarRnaSeq and Significantly Differentially Expressed in SARS-CoV-2 Infected vs Uninfected Controls Across 3 Time Points. Significant correlations between miRNA-mRNA for SARS-CoV-2 infected vs uninfected control cells differentially miRNA and mRNA expression (P < 0.05). Pink cell color signifies previously known miRNA-mRNA interactions (Tarbase v8), and green cell color represents known associated with endothelial damage due to SARS-CoV-2 infection [38]. Correlation value is the level of inverse correlation of miRNA and mRNA regulation estimated by mirTarRnaSeq observed in the dataset (− 1,0), where − 1 is at the most inverse correlation observed in the dataset). Target scan CSP represents context score percentile (between 1 and 100, where 100 is the highest score possible). mirTarRnaSeq p value calculation is described in the results section, the DE p value is estimated from differential expression analysis performed using DESeq2. NA represents a site not predicted as the target of miRNA by TargetScan

From: mirTarRnaSeq: An R/Bioconductor Statistical Package for miRNA-mRNA Target Identification and Interaction Analysis

miRNA

Gene Symbol

Correlation Value

miRanda Score

TargetScan CSP

mirTarRnaSeq p value

p value mRNA DE

p value miRNA DE

hsa-miR-17-5p

SSH1

−0.99

169

94

0.01807

0.001407784

0.00074288

hsa-miR-93-5p

MAPK1

−0.99

169

96

0.0005

0.038078634

0.001500608

hsa-miR-93-5p

HOMER2

−0.99

169

NA

0.00293

0.028214162

0.001500608

hsa-miR-23c

ABL2

−0.99

173

74

0.00136

0.027869177

0.0258363

hsa-miR-374a-5p

LARP1

−0.99

171

65

0.03374

0.01177344

4.25E-11

hsa-miR-429

LONRF2

−0.99

169

68

0.02127

0.018978845

1.01E-05