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Table 2 Comparison between survival-related genes and cancer driver genes

From: Survival-related genes are diversified across cancers but generally enriched in cancer hallmark pathways

Cancer Type

# of SRGsa

DriverDBV3

Mutationb

CNV

Methylation

Log-Rank Test

 KIRC

7770

46.9%

(340/725) **

0%

(0/3)

50%

(6/12)

 LGG

6691

32.5%

(570/1752)

82.2%

(37/45) ***

–

 

 ACC

5243

19.7%

(74/375)

32.3%

(40/124)

–

 

 UVM

3765

25%

(9/36)

62%

(75/121) ***

–

 

 LIHC

2359

9.5%

(106/1113)

9.6%

(8/83)

6.6%

(12/181)

 PRAD

1538

5.1%

(58/1141)

23.5%

(4/17)

4.4%

(3/68)

 MESO

586

2.5%

(1/40)

0%

(0/1)

–

 

 PAAD

443

1.6%

(16/971)

0%

(0/2)

16%

(4/25)**

 KIRP

238

1.9%

(12/631)

1.1%

(1/87)

2.2%

(5/224)

 BLCA

39

0.2%

(6/2404)

0%

(0/104)

0%

(0/443)

 CESC

35

0.2%

(4/1815)

0%

(0/52)

–

 

 LAML

29

0%

(0/413)

0%

(0/3)

–

 

 HNSC

18

0%

(0/1914)

1%

(1/103)

0%

(0/89)

 STAD

10

0.1%

(4/3695)

0%

(0/86)

–

 

 LUAD

8

0%

(1/2903)

0%

(0/37)

0%

(0/18)

 SKCM

1

0%

(0/4559)

0%

(0/18)

–

 

Cox Regression

 KIRC

7091

38.3%

(278/725)

0%

(0/3)

50%

(6/12)

 ACC

6467

25.9%

(97/375)

43.5%

(54/124)

–

 

 UVM

5600

33.3%

(12/36)

84.3%

(102/121) ***

–

 

 LGG

5418

27.2%

(476/1752)

42.2%

(19/45) ***

–

 

 PAAD

4287

21.2%

(206/971)

0%

(0/2)

36%

(9/25)*

 LIHC

2384

10%

(111/1113)

8.4%

(7/83)

9.9%

(18/181)

 PRAD

2068

8.1%

(92/1141)

35.3%

(6/17) *

5.9%

(4/68)

 MESO

728

2.5%

(1/40)

0%

(0/1)

–

 

 KIRP

592

2.4%

(15/631)

2.3%

(2/87)

1.8%

(4/224)

 BLCA

442

2.7%

(64/2404)

1%

(1/104)

1.6%

(7/443)

 KICH

407

3.7%

(2/54)

–

 

–

 

 CESC

230

1.4%

(25/1815)

0%

(0/52)

–

 

 HNSC

204

0.9%

(17/1914)

1.9%

(2/103)

0%

(0/89)

 LAML

158

0.7%

(3/413)

0%

(0/3)

–

 

 LUAD

71

0.4%

(12/2903)

5.4%

(2/37) **

0%

(0/18)

 PCPG

64

2%

(1/49)

0%

(0/5)

–

 

 BRCA

24

0.1%

(2/2162)

0%

(0/220)

0%

(0/36)

 UCEC

5

0%

(0/6669)

0%

(0/76)

–

 

 STAD

3

0%

(1/3695)

0%

(0/86)

–

 

 SARC

2

0%

(0/543)

0%

(0/104)

–

 

 THCA

2

0%

(0/192)

0%

(0/3)

0%

(0/201)

  1. Note: Fisher’s exact test of SRGs and cancer driver genes; *p < 0.05, **p < 0.01, ***p < 0.001, one-tailed. The first number in the parentheses indicates the count of overlapping genes between SRGs and cancer driver genes, and the second number indicates total driver genes that are also applicable genes in specified cancer
  2. - Not available; no driver genes were described in those cancer types
  3. aSRGs for both models are defined as FDR < 0.05
  4. bMutation-based driver genes were merged based on 14 tools summarized by DriverDBV3