Fig. 4
From: Diabetes risk loci-associated pathways are shared across metabolic tissues
Diabetes eQTLs linked to immune system-related pathways. a eQTLs associated with the Antigen processing and presentation pathway driven by rs601945. X-axis tissues investigated, y-axis eGenes and eQTLs. b Effect of rs601945 on HLA-DQA2 mRNA expression in the skeletal muscle. X-axis, genotype; y-axis, normalized expression levels. c Effect of rs12719778 on HLA-DQB1 mRNA expression in the skeletal muscle. X-axis, genotype; y-axis, normalized expression levels. d Circos plot of the rs601945 locus. Chromatin interactions in blood cells (CD34+, CD4+ memory, CD4+ naïve and CD4+ T) of the region that is in LD (r2 ≥ 0.8, lead SNP is shown in red) with rs601945 are shown as colored arcs. Chromatin states are shown for CD4+ memory (inner-ring) and CD4+ naïve cells respectively (middle-ring). Genes are shown in the outer ring in gray and red