Fig. 4

Summary of regulatory edges between GTEx normal lung and two lung cancer subtypes. A Bar graphs calculating number of GRN edges between GTEx normal lung tissue samples and LUAD (left panel) or LUSC (right panel) respectively for each category. Blue bars represent the number of regulatory edges in total where TF regulated at least one node in an edge from the LUAD/LUSC specific GCNs. Orange bars represent the number of edges when both TF and TR were differentially expressed. Green bars represent the number of edges when TF/TR ratio was significantly different between normal lung and LUAD or LUSC. Red bars represent the number of significant edges when TF and TR were both DEGs and TF/TR ratio is significantly different. For those significant edges, purple bars represent TF was down-regulated in cancer while TR was up-regulated in cancer; brown bars represent TF was up-regulated in cancer while TR was down-regulated in cancer; pink bars represent both TF and TR were down-regulated; and bars represent both TF and TR were up-regulated. B Heatmap distribution of regulatory edges comparing between normal samples and two types of lung cancer with LUAD on the left and LUSC on the right. For DEGs up/down regulation, red means up-regulation in lung cancer, blue means down regulation in lung cancer, and white means not a DEG. For TF/TR ratio, red means the ratio was significantly different between normal and cancer, and grey means the ratio is not different