Table 1 Population characteristics
From: Assessment of a polygenic hazard score for the onset of pre-clinical Alzheimer’s disease
CN (N = 573) | MCI (N = 124) | AD (N = 83) | P-value | |
|---|---|---|---|---|
Sex | ||||
Female | 318 (55.5%) | 56.0 (45.2%) | 48.0 (57.8%) | 0.0859 |
Male | 255 (44.5%) | 68.0 (54.8%) | 35.0 (42.2%) | |
Age (years) | ||||
Mean (SD) | 72.9 (6.12) | 75.6 (7.13) | 75.0 (7.85) | < 0.001 |
Median [Min, Max] | 72.7 [60.0, 93.6] | 76.3 [56.1, 95.4] | 74.8 [57.8, 93.2] | |
APOEε4 | ||||
Absent | 412 (71.9%) | 66.0 (53.2%) | 24.0 (28.9%) | < 0.001 |
Present | 161 (28.1%) | 58.0 (46.8%) | 59.0 (71.1%) | |
Education (years) | ||||
0–6 | 1.00 (0.2%) | 1.00 (0.8%) | 2.00 (2.4%) | 0.0148 |
7–12 | 41.0 (7.2%) | 17.0 (13.7%) | 11.0 (13.3%) | |
9–12 | 213 (37.2%) | 50.0 (40.3%) | 29.0 (34.9%) | |
13–15 | 118 (20.6%) | 22.0 (17.7%) | 20.0 (24.1%) | |
15+ | 200 (34.9%) | 34.0 (27.4%) | 21.0 (25.3%) | |
PHS | ||||
Mean (SD) | 0.0271 (0.763) | 0.415 (0.967) | 0.847 (0.941) | < 0.001 |
Median [Min, Max] | −0.178 [−1.60, 2.59] | 0.162 [−1.26, 3.12] | 1.01 [−1.06, 2.91] | |