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Fig. 4 | BMC Genomics

Fig. 4

From: Stage-specific miRNAs regulate gene expression associated with growth, development and parasite-host interaction during the intra-mammalian migration of the zoonotic helminth parasite Fasciola hepatica

Fig. 4

Fasciola hepatica let-7 isomiRs are highly conserved as mature sequences yet evolutionarily divergent in comparison to their precursor sequences. (a) Phylogenetic tree of let-7 precursor sequences constructed using T-Coffee multiple sequence alignment tool and iTOL v6 (itol.embl.de) with percentage identity scores, 0 = zero sequence difference. (b) Sequence alignment of the mature miRNAs of let-7 from F. hepatica (fhe) Caenorhabditis elegans (cel), Drosophila melanogaster – fruit fly (dme), Echinococcus granulosus (egr), E. multilocularis (emu), Homo sapiens – human (hsa), Mus musculus – mouse (mmu), Schistosoma japonicum (sja), S.mansoni (sma) and Schmidtea mediterranea (sme) using ClustalW. Homology is illustrated through colour coded nucleotides and consensus nucleotides across all mature miRNA sequences.

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BMC Genomics

ISSN: 1471-2164

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