Transcriptomic analysis provides insights into molecular mechanisms of thermal physiology

BMC Genomics

Table 2 Heart Significant Modules

Module	KEGG Pathway	Module Size	Hub MM	MM	Positive MM	KEGG Terms in Pathway
ME1_heart	MAPK signaling pathway*	194	SAC3D1	0.51	74.70%	K04459
ME1_heart	MAPK signaling pathway*	194	SAC3D1	0.51	74.70%	K20216
ME2_heart	Endocytosis*	147	NCKAP5L	0.52	31.30%	K12471
ME3_heart	FoxO signaling pathway*	281	CLMPB	0.53	23.80%	K11411
ME4_heart	RNA degradation	168	TRAFD1	0.49	32.10%	K03681
ME5_heart	Metabolic pathways	336	LOC105935504	0.39	30.90%	K00166
						K00232
						K03844
						K05546
ME6_heart	NA	554	WNT5B	0.65	34.10%	NA
ME7_heart	NA	454	MOSPD2	0.57	30.60%	NA
ME8_heart	Oxidative phosphorylation*	142	TXLNA	0.45	32.40%	K0393
ME9_heart	Ribosome*	90	YIF1B	0.54	66.70%	K02899

Columns include: Module = identifier for module eigengene (ME, first principal component of module), KEGG Pathway = top KEGG pathway determined by number of KEGG terms, Module Size = number of mRNAs in the module, Hub MM = mRNA with highest correlation with module eigengene, MM = correlation of hub mRNA with module eigengene, Positive MM = proportion of mRNAs with positive MM in the module, KEGG Terms in Pathway = enriched KEGG terms in the listed KEGG pathway.
*Indicates modules where more than one KEGG Pathway had the same number of enriched KEGG terms, in which case the most informative KEGG pathway was selected

ISSN: 1471-2164