Transcriptomic analysis provides insights into molecular mechanisms of thermal physiology

BMC Genomics

Table 3 Heart Significant Module Trait Correlations

Trait	Module	Correl coef	FDR P-value	Hub GS	GS	Positive GS
CTMax 12 °C	ME1_heart	0.49	2.10E-02	GPM6AA	-0.51	54.60%
CTMax 28 °C	ME2_heart	-0.53	9.50E-03	NCKAP5L	-0.50	35.30%
FA 12 °C	ME3_heart	0.50	1.02E-02	PDCD4A	0.55	65.80%
FA 12 °C	ME4_heart	0.53	4.82E-03	RSRC1	-0.58	13.10%
FA 12 °C	ME5_heart	0.55	4.82E-03	RPL5A	0.62	81.80%
heart mass 12 °C	ME6_heart	-0.57	1.80E-03	WRAP53	0.72	48.20%
LKA 12 °C	ME6_heart	-0.65	3.39E-05	LOC118563371	0.80	46.90%
LKA 12 °C	ME7_heart	-0.56	1.29E-03	LOC105934375	0.80	44.70%
WAM 12 °C	ME8_heart	-0.56	1.20E-03	LOC118563115	0.70	36.60%
WAM 12 °C	ME9_heart	-0.55	1.20E-03	LRRC58B	-0.56	10.00%
WAM 12 °C	ME4_heart	-0.54	1.74E-03	LOC118563570	0.61	65.50%
WAM 12 °C	ME5_heart	-0.56	1.20E-03	HPRT1L	0.66	40.50%
	AVERAGE	0.55

Significant heart ME correlations with FDR p < 0.05. Columns include: Trait = traits significantly correlated with a given ME (critical thermal maximum: CT_max, whole animal metabolic rate: WAM, cardiac metabolic rate: CaM with substrates fatty acids = FA, lactate + ketones + ethanol = LKA), Module = identifier for module eigengene (ME, first principal component of module), Correl coef = Pearson’s signed correlation coefficient for trait and ME, FDR P-value = multiple test corrected p-value for trait versus module correlation, Hub GS = mRNA with highest gene significance for the trait in the module, GS = gene significance, correlation between top module mRNA and trait, Positive GS = proportion of mRNAs in the module that are positively correlated with trait

ISSN: 1471-2164