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Table 3 Heart Significant Module Trait Correlations

From: Transcriptomic analysis provides insights into molecular mechanisms of thermal physiology

Trait Module Correl coef FDR
P-value
Hub GS GS Positive GS
CTMax 12 °C ME1_heart 0.49 2.10E-02 GPM6AA -0.51 54.60%
CTMax 28 °C ME2_heart -0.53 9.50E-03 NCKAP5L -0.50 35.30%
FA 12 °C ME3_heart 0.50 1.02E-02 PDCD4A 0.55 65.80%
FA 12 °C ME4_heart 0.53 4.82E-03 RSRC1 -0.58 13.10%
FA 12 °C ME5_heart 0.55 4.82E-03 RPL5A 0.62 81.80%
heart mass 12 °C ME6_heart -0.57 1.80E-03 WRAP53 0.72 48.20%
LKA 12 °C ME6_heart -0.65 3.39E-05 LOC118563371 0.80 46.90%
LKA 12 °C ME7_heart -0.56 1.29E-03 LOC105934375 0.80 44.70%
WAM 12 °C ME8_heart -0.56 1.20E-03 LOC118563115 0.70 36.60%
WAM 12 °C ME9_heart -0.55 1.20E-03 LRRC58B -0.56 10.00%
WAM 12 °C ME4_heart -0.54 1.74E-03 LOC118563570 0.61 65.50%
WAM 12 °C ME5_heart -0.56 1.20E-03 HPRT1L 0.66 40.50%
  AVERAGE 0.55     
  1. Significant heart ME correlations with FDR p < 0.05. Columns include: Trait = traits significantly correlated with a given ME (critical thermal maximum: CTmax, whole animal metabolic rate: WAM, cardiac metabolic rate: CaM with substrates fatty acids = FA, lactate + ketones + ethanol = LKA), Module = identifier for module eigengene (ME, first principal component of module), Correl coef = Pearson’s signed correlation coefficient for trait and ME, FDR P-value = multiple test corrected p-value for trait versus module correlation, Hub GS = mRNA with highest gene significance for the trait in the module, GS = gene significance, correlation between top module mRNA and trait, Positive GS = proportion of mRNAs in the module that are positively correlated with trait