Skip to main content

Table 2 Summary of QTL detected for birth weight in U.S. Red Angus cattle

From: Genome-wide association and genotype by environment interactions for growth traits in U.S. Red Angus cattle

Chr_Mba

-log10 P-value

Regression Beta

MAFb

Supporting SNPsc

Positional Candidate Genes

Lead SNP Location

Scientific Precedence [reference]; organism; trait

6_38

67.949

−3.123

0.283

102

LCORL, LOC782905

Intergenic

[20, 24, 26, 37,38,39,40,41,42,43,44,45]; Cattle; Birth, weaning and yearling weight, fat and protein percentage, carcass weight, fat thickness, dystocia, average daily gain and dry matter intake, hip height, ribeye area, calving ease, stature, feed intake and gain

6_37

47.734

−2.302

0.359

183

NCAPG

Exond

[20, 24, 39, 40, 42,43,44,45]; Cattle; Weaning and yearling weight, calving ease, dystocia, average daily gain, dry matter intake, fetal growth, daily feed intake, muscle growth

14_23

38.772

2.800

0.110

64

PLAG1

3’UTR

[11, 20, 24, 26, 31, 46]; Cattle; Birth weight, mid-test metabolic weight, yearling and carcass weight, stature, milk protein yield, stature

20_05

31.330

1.815

0.436

100

LOC104975192, STC2

Intergenic

[20, 24, 31, 40, 42, 47, 48]; Cattle; Birth, weaning and carcass weight, average daily gain, dry matter intake, stature, mature rate, mid-test metabolic weight

6_36

26.156

−2.267

0.219

63

HERC6

Intron

[20, 40, 42, 49,50,51]; Cattle; Birth, weaning, and yearling weight, mature weight, average daily gain, dry matter intake, backfat thickness, conception rate, milk production traits, protein ubiquitination

14_24

25.908

2.143

0.113

80

LOC112449660, IMPAD1

Intergenic

[20, 24, 26, 29, 31, 46]; Cattle; Birth, weaning, and yearling weight, calving ease, carcass weight, milk and protein yield, stature, stillbirth, body size, mid-test metabolic weight

6_39

21.788

−1.569

0.270

35

LOC782905, SLIT2

Intergenic

[20, 24, 37, 40, 42, 52]; Cattle; Birth, weaning, and yearling weight, calving ease, carcass weight, average daily gain, dry matter intake, backfat thickness, ribeye area, hip height

7_91

17.095

1.339

0.263

70

LOC101905238, ARRDC3

Intergenic

[24, 30, 31, 46, 53]; Cattle; Milk protein yield, chest width and bone quality, calving ease, average daily gain, growth and muscularity, birth, weaning, and yearling weight, ribeye area

20_06

15.122

−1.372

0.382

12

LOC783392, CPEB4

Intergenic

[40, 48, 49, 54, 55]; Cattle; Fat percentage, dry matter intake, mature weight, conception rate, mRNA and protein expression in meiosis regulation

6_35

14.833

−1.305

0.317

32

MMRN1

Exone

[24, 43, 56,57,58]; Cattle, human, sheep; Birth weight, dry matter intake, fetal growth, weaning weight, winter tolerance under metabolic stress response

6_40

14.409

2.002

0.060

47

SLIT2

Intron

[20, 24, 40, 42, 59, 60]; Cattle, mouse; Birth, weaning, and yearling weight, calving ease, average daily gain, carcass weight, hip height, milk fat and protein, development of central nervous system

20_04

11.639

−1.088

0.438

12

SH3PXD2B

Intron

[24, 40, 61]; Cattle, human; Birth and weaning weight, carcass weight, fat thickness, calving ease, average daily gain, development of eyes, heart, and bone

6_41

11.067

1.171

0.264

57

KCNIP4

Intron

[20, 24, 38, 40, 42, 62, 63]; Cattle, human; Birth, weaning, and yearling weight, protein percentage, average daily gain, ribeye area, carcass weight, milk fatty acid composition, potassium channel activity

6_32

9.335

0.985

0.325

57

GRID2

Intron

[40, 42, 46, 64]; Human, cattle; Mammalian nervous system mediation, dry matter intake, average daily gain, birth weight, milk fat yield

6_34

8.662

−1.095

0.285

14

CCSER1

Intron

[20, 49, 58, 65]; Cattle, human, sheep; Birth and weaning weight, conception rate, regulator of mitosis, feed intake

14_25

6.648

0.805

0.311

41

NSMAF, LOC107133116

Intergenic

[20, 24, 29, 31, 40, 47, 59, 66, 67]; Cattle, human; Birth, weaning, and yearling weights, calving ease, carcass weight, average daily gain, dry matter intake, hip height, stature, backfat thickness, ribeye area, lean meat yield, stillbirth, residual feed intake, immune system response

20_07

6.424

0.725

0.378

26

ENC1, LOC112443028

Intergenic

[49, 68, 69]; Cattle, mouse; Conception rate, residual feed intake, development of nervous system

14_22

5.827

−1.153

0.068

15

LOC101906669, TRNAG-UCC

Intergenic

[11, 40, 41]; Cattle; Average daily gain, hip height, protein percentage

14_02

5.239

0.762

0.124

5

SLURP1

3’UTR

[49, 54, 70]; Rat, cattle; Immune response, protein, fat and milk yield, fat and protein percentage, number of breedings until conception

  1. a Chromosome_Megabase
  2. b Minor Allele Frequency
  3. c Single Nucleotide Polymorphisms
  4. d Indicates a predicted nonsynonymous mutation Ile➔Met, exon 9
  5. e Indicates a predicted nonsynonymous mutation Gln➔His, exon 6