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Table 4 Summary of QTL detected for yearling weight in U.S. Red Angus cattle

From: Genome-wide association and genotype by environment interactions for growth traits in U.S. Red Angus cattle

Chr_Mba

-log10 P-value

Regression Beta

MAFb

Supporting SNPsc

Positional Candidate Genes

Lead SNP Location

Scientific Precedence [reference]; organism; trait

6_38

48.689

−24.991

0.282

87

LCORL, LOC782905

Intergenic

[20, 24, 26, 37,38,39,40,41,42,43,44,45]; Cattle; Birth, weaning and yearling weight, fat and protein percentage, carcass weight, fat thickness, dystocia, average daily gain and dry matter intake, hip height, ribeye area, calving ease, stature, feed intake and gain

6_37

36.517

−19.339

0.328

173

FAM184B

Intron

[20, 24, 39, 40, 42]; Cattle; Weaning and yearling weights, calving ease, dystocia, average daily gain, dry matter intake, daily feed intake

20_05

34.429

−18.105

0.441

116

STC2

Exond

[20, 24, 31, 40, 42, 47, 48]; Cattle; Birth, weaning and carcass weight, average daily gain, dry matter intake, stature, mature rate, mid-test metabolic weight

6_36

25.670

−21.048

0.219

49

HERC6

Intron

[20, 40, 42, 49,50,51]; Cattle; Birth, weaning, and yearling weight, mature weight, average daily gain, dry matter intake, backfat thickness, conception rate, milk production traits, protein ubiquitination

6_39

19.104

−14.508

0.271

45

LOC782905, SLIT2

Intergenic

[20, 24, 39, 42, 44, 54]; Cattle; Birth, weaning, and yearling weight, calving ease, carcass weight, average daily gain, dry matter intake, backfat thickness, ribeye area, hip height

14_23

16.513

17.008

0.116

47

PLAG1

3’UTR

[11, 20, 24, 26, 31, 46]; Cattle; Birth weight, mid-test metabolic weight, yearling and carcass weight, stature, milk protein yield, stature

20_06

15.250

−12.790

0.390

24

LOC783392, CPEB4

Intergenic

[40, 48, 49, 54, 55]; Cattle; Fat percentage, dry matter intake, mature weight, conception rate, mRNA and protein expression in meiosis regulation

6_40

13.214

−11.340

0.276

69

KCNIP4

Intron

[20, 24, 42, 56, 59, 60, 63, 66]; Cattle, mouse, human; Birth, weaning, and yearling weights, calving ease, mature weight, average daily gain, carcass weight, hip height, post-weaning weight, liver weight, potassium channel function

6_35

12.635

−11.427

0.315

40

MMRN1

Exone

[24, 43, 56,57,58]; Cattle, human, sheep; Birth weight, dry matter intake, fetal growth, weaning weight, winter tolerance under metabolic stress response

6_34

12.607

−12.734

0.286

36

CCSER1

Intron

[20, 49, 58, 65]; Cattle, human, sheep; Birth and weaning weight, conception rate, regulator of mitosis, feed intake

14_24

12.459

14.915

0.102

42

PENK, LOC112449660

Intergenic

[20, 24, 26, 29, 31, 46, 74]; Cattle, rat; Birth, weaning, and yearling weights, calving ease, carcass weight, milk and protein yield, stillbirth, body size, mid-test metabolic weight, bone development

20_04

10.984

−10.008

0.442

25

SH3PXD2B

Intron

[24, 40, 61]; Cattle, human; Birth and weaning weights, carcass weight, fat thickness, calving ease, average daily gain, development of eyes, heart, and bone

6_41

10.036

8.987

0.486

41

KCNIP4

Intron

[20, 24, 38, 40, 42, 62, 63]; Cattle, human; Birth, weaning, and yearling weight, protein percentage, average daily gain, ribeye area, carcass weight, milk fatty acid composition, potassium channel activity

6_33

9.693

−9.134

0.299

6

CCSER1

Intron

[24, 49, 65]; Cattle, human; Carcass weight, fat thickness, conception rate, regulator of mitosis

7_91

8.726

8.879

0.240

39

LOC112447488, LOC112447489, LOC101905238, ARRDC3

Intergenic

[24, 30, 31, 46, 53]; Cattle; Milk protein yield, chest width and bone quality, calving ease, average daily gain, growth and muscularity, birth, weaning, and yearling weight, ribeye area

20_03

8.002

7.171

0.472

6

KCNIP1

Intron

[78]; Frog, zebrafish; Development of neural plate, associated with cardiac myocytes

  1. a Chromosome_Megabase
  2. b Minor Allele Frequency
  3. c Single Nucleotide Polymorphisms
  4. d Indicates a predicted nonsynonymous mutation Pro➔Ala, exon 2
  5. e Indicates a predicted nonsynonymous mutation Gln➔His, exon 6