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Table 5 Summary of GxE interactions detected for birth weight in U.S. Red Angus cattle

From: Genome-wide association and genotype by environment interactions for growth traits in U.S. Red Angus cattle

Chr_Mba

-log10 P-value

Regression Beta

MAFb

Supporting SNPsc

Positional Candidate Genes

Lead SNP Location

Scientific Precedence [reference]; organism; trait

26_07d

7.340

1.350

0.457

9

PRKG1

Intron

[49, 62, 81, 82]; Cattle, human, mouse; Conception rate, milk fatty acid, and dry matter intake, vasodilation

22_01e

6.910

−1.082

0.277

9

LOC531679, SEC61G

Intergenic

[46, 83,84,85]; Cattle, human; Milk fatty acid, milk protein percentage, metabolic body weight and feed efficiency, essential for translocation of polypeptides to the ER, role in ER stress response, tumor cell growth

22_02e

5.945

0.951

0.346

5

NEK10

Exonf

[46, 84, 86, 87]; Human, cattle; Mitotic response to UV-stress, ciliogenesis in development, metabolic body weight, milk protein percentage

  1. a Chromosome_Megabase
  2. b Minor Allele Frequency
  3. c Single Nucleotide Polymorphisms
  4. d Significant for U.S. Arid Prairie Ecoregion
  5. e Significant for U.S. High Plains Ecoregion
  6. f Indicates a predicted nonsynonymous Ser➔Thr, exon 2
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BMC Genomics

ISSN: 1471-2164

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