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Table 7 Summary of GxE interactions detected for yearling weight in U.S. Red Angus cattle

From: Genome-wide association and genotype by environment interactions for growth traits in U.S. Red Angus cattle

Chr_Mba

-log10 P-value

Regression Beta

MAFb

Supporting SNPsc

Positional Candidate Genes

Lead SNP Location

Scientific Precedence [reference]; organism; trait

12_54d

6.173

207.987

0.027

5

EDNRB, POU4F1

Intergenic

[24, 40, 49, 81, 101, 110,111,112,113,114,115]; Mouse, cattle, human; Neural crest cell proliferation, milk fatty acid, residual feed intake, dry matter intake, conception rate, weaning weight, vasodilation, neural cell fate specification, cardiac development

2_93d

6.002

−204.602

0.021

46

PARD3B

Intron

[40, 116,117,118]; Mouse, cattle; Neurogenesis and cortical development, cell proliferation and differentiation, dendritic spine formation, average daily gain

2_94d

5.957

−203.686

0.034

15

NRP2

Intron

[40, 46, 119,120,121]; Mouse, cattle; Neural development and formation of the central and peripheral nervous systems, vascular development, average daily gain, milk fat yield

13_70e

5.833

11.315

0.295

6

ZHX3

Intron

[88, 94, 122,123,124,125]; Rat, human, cattle; Development of nephritic syndrome, regulation of metabolism, weaning weight, shear force, tenderness response to stress, scrotal circumference, herd life, rump fat thickness, conception rate

28_24f

5.258

−9.747

0.470

7

DNAJC12, SIRT1

Intergenic

[46,47,48, 81, 83, 84, 90,91,92,93]; Cattle, human; Milk fatty acids, milk fat and protein yield, milk fat and protein percentage, body measurements and meat quality, stature, birth weight, calving ease, maturity rate, cell proliferation, senescence in response to cellular stress

  1. a Chromosome_Megabase
  2. b Minor Allele Frequency
  3. c Single Nucleotide Polymorphisms
  4. d Significant for U.S. Foothills Ecoregion
  5. e Significant for U.S. Forested Mountains Ecoregion
  6. f Significant for U.S. Upper Midwest & Northeast Ecoregion