Table 2 Frequent HLA Class I and Class II two-Locus haplotypes in Lebanese Study Subjects
HLA loci | Haplotype | Freq | D' | χ2 | P | HLA Loci | Haplotype | Freq | D' | χ2 | P |
|---|---|---|---|---|---|---|---|---|---|---|---|
A ~ B | A*24:02 ~ B*35:01 | 0.103 | 0.44 | 34.68 | < 1.0 × 10–6 | B ~ DRB1 | B*49:01 ~ DRB1*04:01 | 0.020 | 0.31 | 9.95 | 2.0 × 10–3 |
A*24:02 ~ B*18:01 | 0.028 | 0.22 | 6.69 | 0.010 | B*07:02 ~ DRB1*15:01 | 0.016 | 0.30 | 9.68 | 2.0 × 10–3 | ||
A*02:01 ~ B*41:01 | 0.020 | 0.47 | 14.35 | 1.5 × 10–6 | B*13:01 ~ DRB1*07:01 | 0.016 | 0.52 | 32.25 | < 1.0 × 10–6 | ||
A*02:01 ~ B*40:20 | 0.020 | 0.71 | 23.67 | 1.0 × 10–6 | B*14:02 ~ DRB1*04:01 | 0.016 | 0.26 | 6.53 | 0.010 | ||
A*02:01 ~ B*08:01 | 0.020 | 0.27 | 6.93 | 8.0 × 10–3 | B*15:10 ~ DRB1*15:01 | 0.016 | 0.58 | 20.96 | 5.0 × 10–6 | ||
A*11:01 ~ B*52:01 | 0.020 | 0.26 | 12.20 | 5.0 × 10–4 | B*41:01 ~ DRB1*03:01 | 0.016 | 0.36 | 18.51 | 1.7 × 10–7 | ||
A*11:01 ~ B*14:02 | 0.018 | 0.17 | 5.61 | 0.018 | B*51:02 ~ DRB1*13:01 | 0.016 | 0.40 | 20.96 | 5.0 × 10–6 | ||
A*32:01 ~ B*44:02 | 0.018 | 0.33 | 28.99 | < 1.0 × 10–6 | B*38:01 ~ DRB1*04:01 | 0.013 | 0.42 | 9.76 | 1.8 × 10–5 | ||
A*03:01 ~ B*38:01 | 0.016 | 0.55 | 12.12 | 5.0 × 10–4 | B ~ C | B*35:01 ~ C*04:01 | 0.207 | 0.75 | 170.51 | < 1.0 × 10–6 | |
A*01:01 ~ B*52:01 | 0.015 | 0.30 | 8.69 | 3.0 × 10–3 | B*08:01 ~ C*07:01 | 0.056 | 0.93 | 63.29 | < 1.0 × 10–6 | ||
A*23:01 ~ B*50:01 | 0.014 | 0.41 | 30.08 | < 1.0 × 10–6 | B*18:01 ~ C*12:01 | 0.049 | 0.53 | 45.61 | < 1.0 × 10–6 | ||
A*29:01 ~ B*51:02 | 0.013 | 0.33 | 28.36 | < 1.0 × 10–6 | B*49:01 ~ C*07:01 | 0.046 | 0.91 | 50.63 | < 1.0 × 10–6 | ||
A*30:01 ~ B*13:01 | 0.013 | 0.42 | 32.86 | < 1.0 × 10–6 | B*52:01 ~ C*12:01 | 0.039 | 0.77 | 54.73 | < 1.0 × 10–6 | ||
A*68:01 ~ B*35:01 | 0.013 | 0.56 | 5.72 | 0.017 | B*13:01 ~ C*06:02 | 0.030 | 1.00 | 84.70 | < 1.0 × 10–6 | ||
A*23:01 ~ B*49:01 | 0.012 | 0.27 | 18.80 | 1.5 × 10–7 | B*38:01 ~ C*12:01 | 0.026 | 1.00 | 48.55 | < 1.0 × 10–6 | ||
A*33:01 ~ B*14:02 | 0.011 | 0.30 | 23.00 | 2.0 × 10–6 | B*50:01 ~ C*06:02 | 0.026 | 0.88 | 65.11 | < 1.0 × 10–6 | ||
B ~ DRB1 | B*35:01 ~ DRB1*11:01 | 0.138 | 0.31 | 19.65 | 9.0 × 10–6 | B*15:10 ~ C*07:01 | 0.023 | 0.82 | 22.30 | 2.0 × 10–6 | |
B*08:01 ~ DRB1*03:01 | 0.039 | 0.64 | 86.59 | < 1.0 × 10–6 | B*07:02 ~ C*15:02 | 0.020 | 0.43 | 42.32 | < 1.0 × 10–6 | ||
B*52:01 ~ DRB1*15:01 | 0.039 | 0.77 | 72.64 | < 1.0 × 10–6 | B*40:20 ~ C*03:02 | 0.020 | 0.73 | 70.38 | < 1.0 × 10–6 | ||
B*18:01 ~ DRB1*01:01 | 0.020 | 0.35 | 21.11 | 4.0 × 10–6 | B*41:01 ~ C*17:01 | 0.016 | 0.54 | 65.15 | < 1.0 × 10–6 | ||
B ~ C | B*51:02 ~ C*16:04 | 0.016 | 0.48 | 63.78 | < 1.0 × 10–6 | DRB1 ~ DQB1 | DRB1*13:01 ~ DQB1*06:01 | 0.049 | 0.52 | 37.60 | < 1.0 × 10–6 |
B*44:02 ~ C*05:01 | 0.013 | 0.79 | 53.31 | < 1.0 × 10–6 | DRB1*04:01 ~ DQB1*03:02 | 0.046 | 0.92 | 81.44 | < 1.0 × 10–6 | ||
B*44:02 ~ C*16:04 | 0.013 | 0.36 | 23.19 | < 1.0 × 10–6 | DRB1*07:01 ~ DQB1*02:01 | 0.046 | 0.57 | 43.45 | < 1.0 × 10–6 | ||
B*53:01 ~ C*04:01 | 0.013 | 0.73 | 8.03 | 4.0 × 10–3 | DRB1*14:01 ~ DQB1*05:01 | 0.046 | 0.92 | 71.35 | < 1.0 × 10–6 | ||
B*57:01 ~ C*07:01 | 0.013 | 0.46 | 5.78 | 0.016 | DRB1*01:01 ~ DQB1*05:01 | 0.043 | 0.84 | 59.61 | < 1.0 × 10–6 | ||
DRB1 ~ DQB1 | DRB1*11:01 ~ DQB1*03:01 | 0.309 | 0.83 | 139.70 | < 1.0 × 10–6 | DRB1*16:01 ~ DQB1*05:01 | 0.026 | 1.00 | 43.82 | < 1.0 × 10–6 | |
DRB1*15:01 ~ DQB1*06:01 | 0.105 | 0.90 | 161.82 | < 1.0 × 10–6 | DRB1*10:01 ~ DQB1*05:01 | 0.023 | 1.00 | 38.21 | < 1.0 × 10–6 | ||
DRB1*03:01 ~ DQB1*02:01 | 0.079 | 0.95 | 138.72 | < 1.0 × 10–6 |