Transcriptional changes in the peripheral blood leukocytes from Brangus cattle before and after tick challenge with Rhipicephalus australis

Table 2 Top significant DEGs from the comparison between 12-week tick-exposed and tick-naive steers

Symbol	Entrez ID	Name	Log₂FC^a	p-val	FDR^b
SMPD3	514,201	sphingomyelin phosphodiesterase 3	4.26	3.83E-04	9.50E-03
ALOX15	282,139	arachidonate 15-lipoxygenase	3.71	4.04E-03	3.59E-02
GATA1	516,066	GATA binding protein 1	3.19	1.16E-04	5.38E-03
CCR3	408,018	C-C motif chemokine receptor 3	3.17	1.91E-04	6.90E-03
LOC100297044	100,297,044	C-C motif chemokine 14	3.13	3.53E-03	3.32E-02
GPAT2	526,739	glycerol-3-phosphate acyltransferase 2, mitochondrial	3.11	1.03E-06	6.95E-04
LOC100848006	100,848,006	uncharacterized LOC100848006	3.02	1.56E-03	2.12E-02
HRH4	783,354	histamine receptor H4	2.98	1.34E-03	1.93E-02
LOC104969122	104,969,122	uncharacterized LOC104969122	2.90	6.90E-05	4.32E-03
ALOX5	404,074	arachidonate 5-lipoxygenase	2.72	3.31E-03	3.21E-02
PDLIM1	614,675	PDZ and LIM domain 1	2.64	4.80E-05	3.64E-03
HBB	280,813	hemoglobin, beta	2.53	1.82E-05	2.60E-03
BMPR1B	407,128	bone morphogenetic protein receptor type 1B	2.50	2.66E-05	2.87E-03
MUC13	100,295,610	mucin 13, cell surface associated	2.49	1.09E-06	6.95E-04
FOS	280,795	Fos proto-oncogene, AP-1 transcription factor subunit	−2.70	5.90E-07	5.46E-04
GRO1	281,212	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	−3.43	7.30E-06	1.71E-03

^a log₂FC represents the fold change in gene expression between 12-week tick-exposed (T12 sample set) and tick-naïve steers (T0 sample set). Table displays genes above threshold |logFC| > 2.5
^b FDR represents the false discovery rate (Benjamini-Hochberg multiple test correction of the p-value). Table displays genes below threshold FDR < 0.05

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