Ectopic expression of a combination of 5 genes detects high risk forms of T-cell acute lymphoblastic leukemia

BMC Genomics

Table 1 Clinical characteristics and oncogenetic stratification of our training (RNA-seq data, n = 54) and test (RT-qPCR data, n = 32) cohorts of adult T-ALL patients

Characteristics	Number of patients	N/F		p value	NFRP		p value
Characteristics	Number of patients	Mutation	WT	p value	class I	class II	p value
Total	86	67	19	/	53	33	/
Gender, male/female
Male	58	47	11	0.406	36	22	1.0
Female	28	20	8	0.406	17	11	1.0
Age, years, > 35y
< 35	53	43	10	0.427	36	17	0.172
≥ 35	33	24	9	0.427	17	16	0.172
WBC, × 10⁹/L
≤ 100	68	52	16	0.751	43	25	0.593
> 100	18	15	3	0.751	10	8	0.593
Immunophenotype
ETP	27	20	7	0.584	12	15	0.033
non-ETP	59	47	12	0.584	41	18	0.033
Karyotype
Normal karyotype	43	33	10	0.215	25	18	0.218
Abnormal karyotype	31	28	3	0.215	23	8	0.218
CR
Yes	61	49	12	0.405	38	23	1.0
No	25	18	7	0.405	15	10	1.0
MRD-Induction
≥ 10^4	45	33	12	0.290	24	21	0.117
< 10^4	38	32	6	0.290	27	11	0.117

NFRP class I: positive for NOTCH1/FBXW7 (N/F) and negative for RAS and PTEN mutations (n = 53); NFRP class II: other mutational status (negative for NOTCH1/FBW7 (N/F) and/or positive for RAS and PTEN mutations) (n = 33). EFS, Event-free survival; WBC, White Blood Cells counts; ETP, Early T cell Precursors; CR, complete remission; MRD, Minimal Residual Disease; p-value determined by using two-sided Fisher's exact test

ISSN: 1471-2164