Table 4 10 significantly enriched up- and down-regulated pathways in the natural low temperature acclimation group(N vs T)

Cellular Processes

Signaling pathways regulating pluripotency of stem cells

ko04550

8

up

5.15E-08

ATBF1|FZD9_10|ATBF1|FZD4|ATBF1|

ISL1|ATBF1|WNT1|

Organismal Systems

Protein digestion and absorption

ko04974

18

up

5.25E-05

PRSS1_2_3|NCX|PEPT1|COL9A|COL18A|COL5AS|DPP4|PEPT1|COL18A|NHE3|COL4A|COL2A|COL13A|COL4A|CD26|SLC16A10|COL5AS|KCNQ1|

Organismal Systems

Circadian entrainment

ko04713

13

up

0.001528

NOS1|GRIN1|PLCB|ADCY9|CALM|PKA|PLCB|GNG13|PRKCA|ADCY5|PRKG1|ADCY1|CALM|

Organismal Systems

GABAergic synapse

ko04727

7

up

0.002846

GAD|GNAI|ADCY9|PRIP|GAD|NSF|VGAT|

Organismal Systems

Insulin signaling pathway

ko04910

20

up

0.006257

JNK|FASN|FASN|FASN|PRKAR|FASN|PPP1C|CALM|PKA|INS|FASN|BRAF|FASN|FASN|FASN|FASN|CALM|PIK3CA_B_D|FASN|FASN|

Environmental Information Processing

PI3K-Akt signaling pathway

ko04151

5

up

0.021109

HSP90|COL4A|BRCA1|COL4A|LAMC1|

Environmental Information Processing

AMPK signaling pathway

ko04152

31

down

0.001212

EEF2|PFKFB4|CAMKK2|PFKFB2|CREB3|SCD|EEF2|EEF2|PCK|PFKFB1|PFKFB2|EEF2|IRS1|PDPK1|PPP2R1|PPP2C|SREBF1|CD220|AKT|EEF2|EEF2|EEF2|CCNA|FBP|FOXO3|RHEB|SCD|SIRT1|PFK|SCD|desC|

Organismal Systems

Longevity regulating pathway - multiple species

ko04213

24

down

0.001681

HSPA1_8|CRYAB|CRYAB|CRYAB|CRYAB|SOD1|HSPA1_8|IRS1|E4.6.1.1|HSPA1_8|CD220|FOXA2|AKT|HSPA1_8|FOXO3|SIRT1|CRYAB|HSPA1_8|CRYAB|HSPA1_8|HSPA1_8|HSPA1_8|EIF4EBP2|HSPA1_8|

Metabolism

Glutathione metabolism

ko00480

15

down

0.012074

ANPEP|HPGDS|GGCT|SMS|HPGDS|CD224|GST|HPGDS|GST|HPGDS|GST|HPGDS|GST|CD13|ANPEP|

Metabolism

Citrate cycle (TCA cycle)

ko00020

26

down

0.018255

SDHA|OGDH|LSC2|PC|CS|ACO|MDH2|aceF|IDH1|IDH2|IDH3|ACLY|PCK|SDH1|SDH2|SDH3|SDH4|icd|fumC|sucA|lpd|pdhD|SDHD|SDHB|DLD|DLAT|