Table 2 Allele frequency of SNPs associated with drug resistancea
Antibiotic resistance | Gene | Aminoacid change | Frequency T2DMb (n = 74) n(%) | Frequency TBc (n = 74) n(%) | Frequency Total (n = 148) n(%) |
|---|---|---|---|---|---|
Isoniazid | katG | S315T | 44 (59.4%) | 47 (63.5%) | 91 (61.4%) |
fabG1-inhA | c15t | 28 (37.8%) | 34 (45.9%) | 62 (41.8%) | |
Rifampicin | rpoB | S450L | 28 (37.8%) | 30 (40.5%) | 58 (39.1%) |
rpoB | H445D | 5 (6.7%) | 11 (14.8%) | 16 (10.8%) | |
rpoB | D435Y | 2 (2.7%) | 6 (8.1%) | 8 (5.4%) | |
rpoB | H445L | 4 (5.4%) | 0 | 4 (2.7%) | |
rpoB | S441L | 1 (1.3%) | 0 | 1 (0.6%) | |
rpoB | Q432P | 1 (1.3%) | 0 | 1 (0.6%) | |
rpoB | Q432L | 1 (1.3%) | 0 | 1 (0.6%) | |
rpoC | V483G | 8 (10.8%) | 10 (13.5%) | 18 (12.1%) | |
rpoC | V483A | 3 (4.0%) | 2 (2.7%) | 5 (3.38%) | |
Streptomycin | rpsL | K88R | 7 (9.4%) | 15 (20.2%) | 22 (14.8%) |
rpsL | K43R | 4 (5.4%) | 14 (18.9%) | 18 (12.1%) | |
Ethambutol | embB | M306I | 12 (16.2%) | 9 (12.1%) | 21 (14.1%) |
embB | Q497R | 5 (6.7%) | 12 (16.2%) | 17 (11.4%) | |
embB | S297A | 4 (5.4%) | 9 (12.1%) | 13 (8.7%) | |
Pyrazinamide | pncA | D49G | 5 (6.7%) | 6 (8.1%) | 11 (7.4%) |
pncA | L120P | 7 (9.4%) | 2 (2.7%) | 9 (6.8%) | |
Fluoroquinolone | gyrA | A90V | 4 (5.4%) | 6 (8.1%) | 10 (6.7%) |
gyrA | D94G | 4 (5.4%) | 3 (4.0%) | 8 (5.4%) |