Structural variants and tandem repeats in the founder individuals of four F2 pig crosses and implications to F2 GWAS results

Table 4 Summary of published data on functional biological roles of the top five gene selection

Gene name	Trait	Published data related to top five genes selection
ZFAND5	ADG	Large loss of muscle mass [41]
AP2A2	ADG	Regulation of lipolysis in adipose tissue [50]
HMGCLL1	ADG, CRCL	Ketogenesis [1]
PRIM2	ADG, BFT	Obesity in humans [38]
COL21A1	ADG, BFT, MFR, and CRCL	Body length in fish [26], directional cell migration in development in C. elegans [40]
SHANK2	ADG, BFT, MFR	Autism spectrum disorders [47]
TNNT3	BFT, MFR	Regulate muscle contraction, required for growth and postnatal survival [36]
STX, MRPL16 and CBLIF	BFT, MFR	Residual Feed Intake in beef cattle [65]
ISL1	BFT, CRCL	Regulating pancreatic development and insulin secretion [75]
PLPP7	MFR	Muscle function, muscle growth [60]
PRRC2B	MFR	Growth in fish [78]
RALGPS1 and XKR6	MFR	Body fat ratio [61]
ASTN2	MFR	Plasma triglyceride concentration [35]
VDR	MFR	Body fat [48]
VTI1B	MFR	Body weight [2]
BTRC	MFR	Fatty acid composition in intramuscular fat [16]
IGFBP5	MFR	Lipid metabolism and insulin sensitivity [74]
AOAH	MFR	Fat deposition in chicken [15]
DAAM2	CRCL	Decreased body length [53]
NOCT	CRCL	Susceptibility to Diet-Induced Obesity [28]
PON2	CRCL	Susceptibility to Diet-Induced Obesity [66]
ASB4	CRCL	Feeding behavior and metabolic rate [43]
SPPL3	CRCL	Decreased body weight [68]
PLCB1 and PLCB4	CRCL	Decreased body size [39], Growth and body size [4]

ISSN: 1471-2164