Table 1 Duplex Sequencing mutation frequencies and lacZ assay mutant frequencies in the bone marrow of the same MutaMouse animals exposed to BaP
Assay | Dose (mg/kg/day) | Mean MFa (× 10− 7) | SD (× 10− 7) | Fold Changeb | Variance (× 10− 16) | p value |
|---|---|---|---|---|---|---|
DS | 0 | 1.3 | 0.25 | 6.1 | ||
12.5 | 3.3 | 0.3 | 2.5 | 8.9 | 2.7 × 10−9 | |
25 | 6.8 | 0.64 | 5.2 | 41 | 6.7 × 10−14 | |
50 | 10.4 | 0.7 | 8.0 | 48 | 6.7 × 10−16 | |
(× 10−5) | (× 10−5) | (× 10−11) | ||||
lacZ | 0 | 4.3 | 0.6 | 3.7 | ||
12.5 | 109.4 | 24.3 | 25.3 | 5890 | 1.3 × 10−13 | |
25 | 313.6 | 57.4 | 72.3 | 32,900 | < 1.0 × 10−16 | |
50 | 572.8 | 157.1 | 133 | 216,000 | < 1.3 × 10− 16 |