Fig. 1

Conserved domains of Variable Immunoglobulin-like (VIgL) genes in Aplysia californica. Multiple sequence alignment of two previously identified Aplysia FREP proteins (NP_001191528/LOC100533300 and NP_001191643/LOC100533436) and two putative CREP proteins (XP_005106994/ LOC101862063 and XP_005100118/ LOC101860578) identified by InterProScan conserved domains. Above the alignment, a set of lines demarcate the protein domains of the two previously described Aplysia FREPs as reported in [27]. Dashed line above sequence alignments demarcates signal peptide. Dotted line demarcates immunoglobulin superfamily (IgSf) domains. Solid line demarcates the carbohydrate binding domains. Conserved cysteine residues of VIgLs IgSf domains are highlighted in yellow. Note that the putative CREPs only contain one IgSf domain and thus the signal peptides alignments extend into the region demarcated as IgSF1 for the FREPs