Fig. 4

The association of m⁶A-circRNAs and m⁶A-mRNA in OSCC. A Schematic diagram illustrated the biogenesis of m⁶A-circRNAs and m⁶A-mRNA in OSCC cells. The m⁶A modification was installed by identical m⁶A methyltransferase complex (m⁶A writers). Red A indicated the m⁶A modification site. B Schematic diagram presented the genomic structure of m⁶A-mRNA, unmethylated circRNAs and m⁶A-circRNAs. C c-Myc mRNA acted as a representative for m⁶A-mRNA, which was methylated at 3’-UTR and without circRNA derived. D circHIPK3 (hsa_circ_0000284) represented the group of circRNAs without m⁶A modification in neither circular transcripts nor host gene. E CircFOXM1 (hsa_circ_0025039) represented the group of circRNAs without m⁶A modification in circRNA transcript, however, their host genes were m⁶A-modified at 3’-UTR. F CircKRT5 (hsa_circ_0026457) represented the group of circRNAs only m⁶A-modified in circRNA transcript, instead of host genes. G CircIPO9 (hsa_circ_0015936) represented the group of circRNAs m⁶A-modified both in circRNA transcript and their host genes